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Erythropoietin-Producing Organoid Precursor, Production Method Thereof, and Method For Treating Erythropoietin-Related Disorder
Erythropoietin-Producing Organoid Precursor, Production Method Thereof, and Method For Treating Erythropoietin-Related Disorder
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机译:产生促红细胞生成素的类器官前体,其生产方法以及治疗促红细胞生成素相关疾病的方法
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摘要
The subject of the present invention is to provide a means to producing an erythropoietin-producing organoid using mesenchymal stem cell derived from a mammal. It is a method for producing erythropoietin-producing organoid (organ-like structure) precursor, comprising the step of transplanting mesenchymal stem cell derived from a mammal into an embryo within a pregnant mammalian host or an embryo separated from a pregnant mammalian host to thereby induce the differentiation of the mesenchymal stem cell, in particular, a site to which the mesenchymal stem cell is to be transplanted is a nephrogenic site of the embryo, and a timing of transplantation corresponds to the stage in which a immune system of the host is still immunologically tolerant.
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