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Phosphoinositide Modulation For The Treatment Of Neurodegenerative Diseases
Phosphoinositide Modulation For The Treatment Of Neurodegenerative Diseases
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机译:磷酸肌醇调节治疗神经退行性疾病
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摘要
The present invention relates to the use of agents that inhibit the toxic effects of amyloid oligomers by increasing intracellular levels of phosphoinositol 4-phosphate (PI(4)P, or “PIP”) and/or phosphotidylinositol 4,5-biphosphate (PI(4,5)P2 or “PIP2”), the use of such agents for the treatment of neurodegenerative diseases, methods of treating neurodegenerative diseases by administration of agents which alter lipid metabolism, and methods of identifying agents which alter the association of presenilins with γ-secretase and lipid rafts.
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