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(3R)-HYDROXYACYL-ACP DEHYDRATASE ENZYMES USED IN THE BIOSYNTHESIS OF MYCOLIC ACIDS AND USE OF SAME FOR SCREENING ANTIBIOTICS

机译：（3R）-羟基-ACP脱氢酶用于霉菌酸的生物合成及其用于筛选抗生素的用途

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摘要

The invention relates to (3R)-hydroxyacyl-ACP dehydratase enzymes involved in the biosynthesis of mycolic acids, and to the use of same for screening antibiotics, medicaments that can be used to treat infections in humans or in animals, caused by Corynebacterineae, more specifically infections caused by pathogenic mycobacteria (Mycobacterium tuberculosis, M. africanum, M. leprae, M. ulcerans, M. microti, M. bovis, M. abscissus, M. avium, M. fortuitum, M. kansasii . . . ), and infections caused by other genera such as Nocardia, Rhodococcus, Gordona . . .

机译：本发明涉及参与霉菌酸生物合成的（3R）-羟酰基-ACP脱水酶，及其涉及用于筛选抗生素的药物的用途，所述药物可用于治疗人或动物由引起的感染棒状杆菌科（Corynebacterineae），更具体地说是由致病性分枝杆菌引起的感染，密西西比州（M. kansasii）以及其他属如诺卡氏菌，红球菌，戈多纳（Gordona）引起的感染。。。 展开▼

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公开/公告号US2010143940A1

专利类型

公开/公告日2010-06-10

原文格式PDF

申请/专利权人 ANNAIK QUEMARD;MAMADOU DAFFE;EMMANUELLE SACCO;THOMAS ALWYN JONES;ADRIAN SUAREZ COVARRUBIAS;KRISTINA BACKBRO;
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申请/专利号US20080526452

发明设计人 THOMAS ALWYN JONES;ADRIAN SUAREZ COVARRUBIAS;EMMANUELLE SACCO;MAMADOU DAFFE;ANNAIK QUEMARD;KRISTINA BACKBRO;
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申请日2008-02-08

分类号G01N33/573;C12Q1/34;C12N9/14;C12N1/20;C12N15/63;C07H21/04;

国家 US

入库时间 2022-08-21 18:52:42

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