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Mobilization of a complete cells mixture with embryonic like stem cells from the peripheral blood

机译:动员完整的细胞混合物与来自外周血的胚胎样干细胞

摘要

Disclosed is a method to recover a mixture cell population consisting of a complete profile of progenitor cells including embryonic like stem cells (a “complete progenitor cell mixture” or CPM) from the peripheral blood of an individual by administering to that individual a combination of at least one or more from the category of growth factors and hormones combining with at least one or more from the category of cell fusion inhibitor compounds, and then recovering peripheral blood progenitor cells from said individual. The hormones and growth factors group should include hGH (human growth hormone) with or without erythropoietin (EPO), but specifically without either G-CSF or GM-CSF. The cell fusion inhibitor group should include a CXCR4 antagonist. Also disclosed is a method for using or preserving such a complete progenitor cells mixture (CPM) for the treatment of diseases.
机译:本发明公开了一种通过向个体的外周血中联合给予其组合从个体的外周血中回收由完整的祖细胞组成的混合物细胞群的方法,所述祖细胞包括胚胎样干细胞(“完全祖细胞混合物”或CPM)。将至少一种或多种来自生长因子和激素的物质与至少一种或多种来自细胞融合抑制剂化合物的物质组合,然后从所述个体中回收外周血祖细胞。激素和生长因子组应包括有或没有促红细胞生成素(EPO)的hGH(人类生长激素),但具体来说应不含G-CSF或GM-CSF。细胞融合抑制剂组应包括CXCR4拮抗剂。还公开了使用或保存这种完整的祖细胞混合物(CPM)来治疗疾病的方法。

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