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MOLECULAR DETERMINANTS ASSOCIATED WITH ENHANCED ABILITY TO ENTER CELLS EXPRESSING CXCR4
MOLECULAR DETERMINANTS ASSOCIATED WITH ENHANCED ABILITY TO ENTER CELLS EXPRESSING CXCR4
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机译:与进入CXCR4表达细胞的能力增强相关的分子决定因素
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摘要
The invention provides a method for determining whether a human immunodeficiency virus is likely to be have enhanced ability to enter a cell expressing CD4 and CXCR4 relative to a reference HIV. In certain aspects, the methods comprise detecting one or more amino acid in an envelope protein of the HIV associated with enhanced ability to enter CD4- and CXCR4-expressing cells and determining that the HIVs ability to enter such cells is enhanced relative to a reference HIV, e.g., an HIV that does not comprise such amino acid(s).
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