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Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases
Specific inhibitors of NFAT activation by calcineurin and their use in treating immune-related diseases
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机译:钙调神经磷酸酶激活NFAT的特异性抑制剂及其在治疗免疫相关疾病中的用途
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摘要
Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.
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