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MECHANISM TO SIGNAL RECEPTOR-LIGAND INTERACTIONS WITH LUMINESCENT QUANTUM DOTS
MECHANISM TO SIGNAL RECEPTOR-LIGAND INTERACTIONS WITH LUMINESCENT QUANTUM DOTS
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机译:发光量子点与信号受体-配体相互作用的机理
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摘要
Semiconductor quantum dots are becoming valuable analytical tools for use in biomedical applications. Indeed, their unique properties offer the opportunity to design luminescent probes for imaging and sensing with unprecedented performance. In this context, we have identified operating principles to transduce supramolecular association of complementary receptor-ligand binding pairs into enhancement or suppression in the luminescence of sensitive quantum dots. Thus, complementary receptor-ligand binding pairs can be identified with luminescence measurements relying on our design logic. In fact, we have demonstrated with a representative example that our protocol can be adapted to signal receptor-ligand binding.
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