METHODS FOR PREVENTING HEMATOLOGICAL MALIGNANCIES AND GRAFT VERSUS HOST DISEASE BY ANTI-CD3 PRECONDITIONING

摘要

Graft versus host disease (GVHD) may be prevented, while preserving a beneficial by graft versus leukemia (GVL) effect, in a subject receiving an allogeneic hematopoietic cell transplant by preconditioning the subject with a CD3 modulator, such as an agonistic anti-CD3 antibody. More than one CD3 modulator may be administered at one time. This method may be performed alone or in conjunction with irradiation of the subject. The use of anti-CD3 to precondition a subject to reduce tissue release of chemokines and prevents tissue dendritic cell migration to draining lymph nodes is also provided. Anti-CD3 preconditioning may also be used to modulate host dendritic cells before hematopoietic cell transplantation.