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Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues
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机译:氨酰基-tRNA合成酶的过表达,可有效生产含有氨基酸类似物的工程蛋白
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摘要
Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine.
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