Conjugate addition products of primary amines and activated acceptors

摘要

We report Michael addition products between primary amines and activated α,β-unsaturated compounds exemplified by diethyl methylenemalonate (DEMM). In various embodiments, the reaction proceeds with high yields in the absence of strong base or Lewis acid catalyst under mild reaction conditions. Depending on the state of steric hindrance in the amine, the reaction products are a double Michael addition product or a so-called vicarious Michael addition reaction product.