Chiral Amine-Catalyzed Asymmetric Conjugate Addition of Aldehydes to α-Phenylselenoenones as Z-Allylating Agents

摘要

The asymmetric alkylation of aldehydes and ketones with chiral amine organocatalysts remains a challenge due to the undesired N-alkylation and deactivation of such amines. On the other hand, optically enriched E-allylation products can be prepared through the chiral aminecatalyzed reactions.1 However, the enantioselective introduction of Z-allyl groups has not been developed to date.