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Synthesis of 13C and 2H substituted methacrylic acid, 13C and 2H substituted methyl methacrylate and/or related compounds

机译:[ 13 C]和[ 2 H]取代的甲基丙烯酸,[ 13 C]和[ 2 H]取代的甲基丙烯酸甲酯和/或相关化合物

摘要

The present invention is directed to labeled compounds of the formulae; embedded image wherein Q is selected from the group consisting of —S(═O)—, and —S(═O)2—, Z is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure ; embedded image wherein R1, R2, R3, R4 and R5 are each independently selected from the group consisting of hydrogen, a C1-C4 lower alkyl, a halogen, and an amino group selected from the group consisting of NH2, NHR and NRR′ where R and R′ are each independently selected from the group consisting of a C1-C4 lower alkyl, an aryl, and an alkoxy group, and X is selected from the group consisting of hydrogen, a C1-C4 lower alkyl group, and a fully-deuterated C1-C4 lower alkyl group.
机译:本发明涉及式的标记的化合物; “嵌入式图像” 其中Q是从由-S(═O)-和-S(═O) 2 -,Z组成的组中选择的选自由1-萘基,取代的1-萘基,2-萘基,取代的2-萘基和具有以下结构的苯基组成的组 ; “嵌入式图像” 其中R 1 ,R 2 ,R 3 ,R 4 和R 5 各自独立地选自氢,C 1 -C 4 低级烷基,卤素和选自NH 的氨基。 > 2 ,NHR和NRR',其中R和R'各自独立地选自C 1 -C 4 低级烷基,芳基,和一个烷氧基,并且X选自氢,C 1 -C 4 低级烷基和完全氘代的C 1 -C 4 低级烷基。

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