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Biomarkers of metabolic responses to hepatic drugs
Biomarkers of metabolic responses to hepatic drugs
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机译:肝药物代谢反应的生物标志物
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摘要
Methods for the measurement and prediction of response to hepatotoxicants and carcinogens through the detection of metabolites in a mammal are provided. The metabolites can be used as biomarkers, including efficacy biomarkers, surrogate biomarkers, and toxicity biomarkers. The methods find use for early prediction of toxicity, target identification/validation, and monitoring of drug efficacy.
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