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Antibody catalysis of enantio- and diastereo-selective aldol reactions
Antibody catalysis of enantio- and diastereo-selective aldol reactions
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机译:对映和非对映选择性醛醇缩合反应的抗体催化
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摘要
Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Characterization of two of these antibodies reveals that they are highly proficient (up to 1000-fold better than any other antibody catalyst) and enantioselective catalysts for aldol and retro-aldol reactions and exhibit enantio- and diastereo-selectivities opposite that of antibody 38C2.
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