Antibody Catalysis of Some Organic and Biochemical Reactions

摘要

In the present investigation, structurally different antigens (haptens) were usedto study whether it was possible to obtain antibody catalysts for the acyl-transfer, Diels-Alder and peptidyl-prolyl cis-trans isomerization reactions. Acyl-transfer reactions, such as hydrolytic reactions are important transformation both in biochemistry and synthetic organic chemistry; the Diels-Alder reaction is synthetically useful in constructing substituted cyclohexens; and the peptidyl-prolyl cis-trans isomerisation reaction is a highly substantial biochemical reaction which plays a significant role in protein folding, transport and transmembrane signalling.