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Compositions and methods for modifying toxic effects of proteinaceous compounds
Compositions and methods for modifying toxic effects of proteinaceous compounds
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机译:改变蛋白质化合物毒性作用的组合物和方法
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摘要
The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS. Also disclosed are methods for producing peptides that inhibit the induction of VLS by ITs and cytokines. Also disclosed are peptides comprising the (x)D(y) sequence to promote the extravasation of other molecules. Toxins mutated in the (x)D(y) motif or active site residues are disclosed for used in vaccines.
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