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Treatment of psychostimulant addiction

机译:心理刺激成瘾的治疗

摘要

The present invention belongs to the field of pharmaceutical industry and relates to a new method for the treatment of psychostimulant addiction, in particular cocaine addiction, or pharmaceutically acceptable acid addition salts thereof, with a therapeutically effective amount of 9,10-didehydro-N-methyl-N-(2-propy-nyl)-6-methyl-8β-aminomethylergo-line in the form of free base or in the form of pharmaceutically acceptable addition salt, in particular the bimaleate salt, as well as pharmaceutical compositions containing said compound. In literature, the compound is also known under code LEK-8829. More particularly, present invention relates to a novel method of treatment for reduction of abstinence symptoms after cocaine withdrawal and for suppression the symptoms of craving for cocaine withdrawal and for suppression the symptoms of craving for cocaine reinforcement, and to the use of said active substance for the preparation of the pharmaceutical composition for the treatment of cocaine addiction. In addition to the treatment of cocaine addiction, the present invention also relates to the method for treatment of the addiction with amphetamine, methamphetamine, dextroamphetamine, 3,4-methylenedioxymethamphetamine and pemoline or acid addition salts thereof.
机译:本发明属于药物工业领域,涉及治疗精神有效成瘾,特别是可卡因成瘾或其药学上可接受的酸加成盐的新方法,其治疗有效量为9,10-二氢-N-。呈游离碱形式或药学上可接受的加成盐,特别是双马来酸盐形式的甲基-N-(2-丙炔基)-6-甲基-8β-氨基甲基麦角啉,以及含有所述复合。在文献中,该化合物在代码LEK-8829下也是已知的。更具体地,本发明涉及一种新的治疗方法,该方法用于减少可卡因戒断后的戒断症状并抑制对可卡因戒断的渴望症状并用于抑制对可卡因强化的渴望症状,并且涉及所述活性物质在药物治疗中的用途。用于治疗可卡因成瘾的药物组合物的制备。除可卡因成瘾的治疗外,本发明还涉及用苯丙胺,甲基苯丙胺,右旋苯丙胺,3,4-亚甲二氧基甲基苯丙胺和匹莫林或其酸加成盐治疗成瘾的方法。

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