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Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region
Porcine Forssman synthetase protein, cDNA, genomic organization, and regulatory region
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机译:猪福斯曼合成酶蛋白,cDNA,基因组组织和调控区
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摘要
The present invention provides porcine Forssman synthetase (FSM synthase) (Globoside α-N-acetylgalactosaminyltransferase) protein, cDNA, and genomic DNA sequence. Furthermore, the present invention includes porcine animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional FSM synthetase. Such animals, tissues, organs and cells can be used in research and in medical therapy, including in xenotransplantation. In addition, methods are provided to prepare organs, tissues, and cells lacking the porcine FSM synthetase gene for use in xenotransplantation.
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