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Nitrogenous heterocyclic compounds and process for making nitrogenous heterocyclic compounds and intermediates thereof

机译:氮杂环化合物及其制备方法

摘要

The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.
机译:本发明提供了含氮杂环化合物及其药学上可接受的盐及其制备方法。该化合物对激酶的磷酸化具有抑制活性,从而抑制了这种激酶的活性。本发明还提供了可用于该方法的中间体化合物,以及由该方法生产的最终产物,及其盐或前药。本发明进一步提供了一种通过抑制激酶的磷酸化来抑制哺乳动物中的激酶和治疗疾病状态的方法,该方法包括向有此需要的患者施用有效量的根据本发明的化合物。

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