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Screening of compounds for OCT3 transporter activity
Screening of compounds for OCT3 transporter activity
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机译:筛选具有OCT3转运蛋白活性的化合物
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摘要
OCT3 is consistently expressed at high levels in brain microvessel endothelial cells. Disclosed herein are assays for determining whether a test material/molecule is a substrate for, and/or is actively transported by, the OCT3 transporter, and therefore a candidate substrate for crossing the blood brain barrier. The assays are useful in screening for therapeutic, cytotoxic or imaging compounds used in the treatment or diagnosis of neurological diseases.
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