Method for the use of ¹¹C carbon monoxide in labeling synthesis of ¹¹C-labelled esters by photo-induced free radical carbonylation

摘要

Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols pretreated by a base are provided. The resultant carbon-isotope labeled esters are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET). Associated kits for PET studies are also provided.