Self assembling Amphiphilic Polymers as antiviral agents for the Prevention of infection in an animal by a virus like the flu or Rabies

摘要

Claim 1: a method for the Treatment or prevention of an infection of an animal by a virus, which comprises administering to the animal a combined Polymer which is essentially the structure of formula (1), comprising a Skeleton formed by the remains of the Alternating S points b and the ramifications of Hydrophilic Polymer blocks,Soluble in water; and has Hydrophobic Side Chains and Z c ligands attached to the remains of the Branch Points, where each side chain C is selected independently from the group consisting of linear or branched hydrocarbons C6 30 optionally substituted with one or More Hydrophilic substituents.Polycyclic hydrocarbons C6 30 optionally substituted with one or more Hydrophilic substituents, and amino acidsEach ligand peptides and Hydrophobic Polymer; Z is regardless a ligand that has specific binding Affinity for the surface of said virus; s is a link or a Spacer Rest; The value of n varies from 3 to about 100; the average value of P varies from 1 to 4; and The average value of R varies from 1 to 8.Claim 2: The Method according to claim 1, wherein at least one ligand is acetilneuramu00ednico acid n - or one of its derivatives.Claim 3: The Method according to claim 2, wherein Said ligand selected from the group consisting acetilneuramu00ednico acid n -, beta methylglucoside acid and 4 - neuramu00ednico acid guanidine didesoxi 2.3 - 2.4 - - - - - acetilneuramu00ednico Dehydrated.Claim 3: The Method according to claim 1, wherein at least one ligand is an Antibody or Antibody fragment that has specific binding Affinity for the surface of the virus. Claim 1: The Method according to claim 4, wherein Said ligand is a fragment F (AB ') 2 derived from human IgG antirabies immune globin.Claim 2: The Method according to claim 1, wherein at least one ligand z is a Peptide selected from the group consisting kdyrgwkhwvyytc, kdyrgwkowvyytc, kgwkhwvyc (NH2) and kgwkowvyc (NH2).