Diaryl 1,2,4 - Oxadiazoles Compounds, Pharmaceutical compositions containing Same, Preparation Process and use as immunosuppressive agents in the treatment of autoimmune diseases and / or chronic inflammatory.

摘要

For example, compounds are useful in the treatment of autoimmune disorders such as multiple sclerosis and other diseases. ILO Convention No. 1: from oxadiazol de formula (1), where R1, R2 refers to h, Hal, CF3, ocf3, CN, ONO2, oh, a, OA; s refers to cor3, so2n2, con (R3) 2, O Z; Q refers to X (CH2) m, (CH2) MX (CH2) m, O UN connection unique; X es-o -,- third...-Coo-o-conr3--2 2 2 2 2 2 2 2 (nnnnnnnnnnnn2 (R3) 2, or "CF3" or "R3" if R1 or R2 is "Hal"; a is a beam splitting or linear tar, and It has 1 to 12 carbon atoms, one or more of which can be replaced by Hal, or3, cour3, CN, n (R3) 2 or het, and one or more non adjacent CH2 groups can be replaced by O, NR3, Co or s and / or CH = ch-o-csc or cyclopentanediol group with 3 to 7 carbon atoms,O refers to cyclopentadienyl or cyclopentadienyl propenyl or cyclopentadienyl propenyl with 3-7 carbon atoms; Z is a discrete or linear tar chain with 1-12 carbon atoms, one or more of which are composed of or3, Coordination3, have (R3), 2, CN, so2a, n (R3) 2 or het and / or one or more CH2 non adjacent groups are - O -,- cool...- third...-NBC...-O-S---SO2- and / or by groups -CH = CH- or -CsC- or cycloalkylene groups having 3 to 7 carbon atoms, or denotes cycloalkyl or cycloalkylalkylene having 3-7 ring C atoms; Hal is F, Cl, Br or I; Ar denotes a monocyclic or bicyclic, saturated, unsaturated or aromatic carbocyclic ring having 6 to 14 carbon atoms, which may be monosubstituted, disubstituted or trisubstituted by Hal, A, OR3, N (R3) 2, NO2, CN, COOR3, CF3, OCF3, CON (R3) 2, NR3COA, NR3CON (R3) 2, NR3SO2A, COR3, SO2N (R3) 2, SOA or SO2A, phenyl, pyridyl- [C (R3) 2] n-COOR3 and / or - O [C (R3) 2] n-CON (R3) 2,Therefore, at least one atom is adjacent to the atom connecting the group with the rest of the molecules, and there is one such substitute; het represents a single or double ring, saturated or heterocyclic aromatic ring, containing 1 to 4 N atoms, or Y / or S atoms, which can be independently replaced, desulfurized or Tristan by Hal (a). -The atoms of the atomic group are combined with the atoms, the atoms, the atoms, the atoms, the atoms, the atoms of the atomic group are combined with the atoms, the atoms are combined with other molecules with one of the substitutes; R3 is h or a;Two sets of R3 gemstones can be added together to form a ring with atoms; n is 0, 1, 2, 3, 4, 5, 6, 7 or 8; m is 1, 2, 3, 4, 5, 6, 7 or 8; and their derivatives, solutions, ceramics, salts and stereoisomers with acceptable efficacy, including mixtures in all their relationships.