1,3,4 - thiadiazole compounds and - 1,3,4 Oxadiazoles,The preparation method and Pharmaceutical compositions useful as inhibitors of phosphodiesterase (PDE) - 7 - (7) for the treatment of diseases related to t cells.Autoimmune diseases, inflammatory, pulmonary, CNS, allergies, cancer and AIDS.

摘要

The Invention provides 1.3,4 - Oxadiazoles having the following formula (i) where:And it s or u, R1 is alkyl, alquenilo, alquinilo, cycloalkyl, aryl, heterocicloalquilo, cicloalquenilo,Or a polycyclic heteroaryl Group, R2 is alkyl, optionally substituted, alquenilo, alquinilo heterocicloalquilo, cycloalkyl, aryl, heteroaryl, cicloalquenilo,Polycyclic group or an optionally substituted, or their Derivatives, pharmaceutically acceptableThe process for their Preparation and their use for the manufacture of a Medicament for the treatment of disorders for which Treatment with an inhibitor of PDE7 is relevant.