Specific antagonist for the growth and Differentiation Factor 8 (gdf8), polynucleotide encoding the amino acids that comprise the antagonist gdf8, host cell and vector comprising the polynucleotide, host Cell comprising the Vector and Method for producing an antagonist

摘要

Molecules associated with growth and Differentiation Factor 8 (gdf8), in particular for gdf8 specific epitopes and other antagonists specific for gdf8 in particular gdf8 Antibody or Antigen Binding Protein or fragment thereof, which can inhibit the activity cdf8 The signal and / or in vitro and in vivo. And an immunoassay was used to detect and quantify the gdf8.And Methods for Diagnosing, Preventing, Improving and Treating Disorders associated with gdf8, e.g. degenerative disorders of muscle, bone and insulin Metabolism. Finally, Pharmaceutical compositions for treating such Disorders using the Antibodies, polypeptides, polynucleotides and vectors.