Benzamide Compound Pharmaceutical composition comprising it and its use for the manufacture of a Medicament useful for selectively antagonize the Kappa opioid rceptores

摘要

That is a composite of benzamide 3-fluoro-4 - [4 - [2 - (3,5 - dimetilfenil) pyrrolidin-1-yl] phenoxy methyl] benzamide, or (S) - 3-fluoro-4 - [4 - [2 - (3,5 - dimetilfenil) pyrrolidin-1-yl methyl] phenoxy] benzamide, or a pharmaceutically acceptable Salt thereof. Pharmaceutical composition containing same.Use of said Compound for the manufacture of a Medicament useful for selectively antagonize the Kappa opioid Receptors, such as withdrawal and to treat Anxiety Disorder using ethyl alcohol, and / or Depression or schizophrenia.Use of such a compound with an inhibitor of the reuptake of norepinephrine tricyclic Tertiary Amine selected from doxepin, Amitriptyline, Clomipramine, imipramine, and (+) - trimipamina, or a pharmaceutically acceptable Salt of the same.