Humanized monoclonal antibody fragment Fab or Fab fragment comprising the, and their use for the manufacture of a Medicament polypeptide Glucagon Receptor Antagonist for the Treatment or prevention of diabetes type 1 or 2

摘要

Humanized monoclonal antibody fragment Fab or Fab fragment that includes, where the Fab fragment is able to bind to the receptors of Rat and murine human glucagon, glucagon and inhibit the binding to each Receptor with a Ki of less than 50nm, Recep polypeptide Antagonists Tor which inhibited the glucagon Hormone glucagon Binding to its receptor.Vector comprising a Nucleic Acid Sequence encoding said or Humanized monoclonal antibody Fab fragment and host Cell comprising a sequence of heterologous polynucleotide encoding said or Humanized monoclonal antibody Fab Fragment.Pharmaceutical composition containing same and their use for the manufacture of a Medicament useful for the Treatment or prevention of diabetes type 1 or type 2 or for Achieving weight loss in a Human.