Derivatives of imidazo 2,1-b 1,3,4 thiadiazole, Pharmaceutical compositions containing Same, and Method for preparing them, and Use thereof for the treatment of tumors and other diseases induced by Kinases

摘要

The pyridan [2,1-b] [1,3,4] p-thiodiazepine derivative in formula (1), R1 is a monosexual anthrax (or an unsubstituted monosexual or non heterosexual) or an unsubstituted double cycle (consisting of 1-4 n, or Y / or S atoms), each of which can be replaced by at least one substitute "Hal", "CH2) nor3, - co-r3 selected from group A, -Co-nr3r3, - Co-N (R3) 2, - (CH2) nnr3r3, - (CH2) NN (R3) 2 and so2n (R3) 2; R2 is A'o CYC; R3 is an independent representation,In R1, a 'and CYC: H, a, oh, OA, ACIO or carboarilo alternative; a represents each other independently,In R1 and R3: non separator or separator tar containing 1-10 C atoms, one or two non adjacent CH2 groups may be replaced by N and / or NH; and / or in addition, 1-7 atoms of h may be replaced by Hal Oh, mofulin and / or ammonia; and a 'indicates that non separator tar or branch has 1-10 C atoms, Among them, 1-7 H atoms can be replaced by CYC, R3, NR3, n (R3), 2, het1 and optional anthrax; het1 is independent of each other,R1 and a ': saturated, unsaturated, unsaturated or preferred singlet or bicyclic heteromorphism, replaced by 1 to 4 N, O and / or S atoms, optionally = O; CYC is expressed independently of each other,R2, R3 and a ': cyclopentanediol with 3-7 C atoms, which can be replaced by - R3, NR3 or - n (R3) 2; Hal independently represents each other,in R1 and A: F, Cl, Br or I; and n is 0, 1, 2, 3 or 4; and / or its physiologically acceptable salts. They are TGF-beta receptor I kinase inhibitors and can be used, inter alia, for the treatment of tumors.