Derivatives of imidazo 1,2-a pyrimidine, Preparation procedure, intermediaries that process, Pharmaceutical compositions containing same and Use thereof as Protein Kinase Inhibitors, met, for the treatment of psoriasis, cancers, and other diseases of the central nervous system

摘要

Claim 1: products of formula (1), in which n = 0, 1, or 2,; X represents a hydrogen Atom or a Halogen Atom, an alkyl radical; R represents a hydrogen Atom, a radical NH2, nhalk or N (alk) 2; ra represents a hydrogen Atom, a Halogen Atom, or a radical - or - - or alkyl, cycloalkyl, aryl or heteroaryl -, - O -, -, - NRD NRD (cycloalkyl) alkyl (aryl) - NRD)NRD - (heteroaryl), alkyl, cycloalkyl, aryl heterocicloalquilo, a radical, or a heteroaryl radical; in all these Radicals Radicals, aryl and heteroaryl alkyl, cycloalkyl, optionally substituted are as follows; RB represents a hydrogen Atom, a Radi Cal - coorc, RC, RC - CO - or a radical with co nrcrd; RC represents a radical alkyl, cycloalkyl,Heterocicloalquilo, aryl and heteroaryl, with all these radical optionally substituted as indicated below; RD represents a hydrogen Atom or a radical alkyl or cycloalkyl Radicals; while all the previously defined alkyl, cycloalkyl, heterocicloalquilo,Aryl and heteroaryl radical optionally substituted with one or more selected from Halogen Atoms and hydroxyl radicals, alkoxy, CN, CF3, nr1r2 -, - COOH, - - - cooalk, conr1r2, nr1cor2, COR1, Oxo, heterocicloalquilo, aryl and heteroaryl, Recent heterocicloalquilo,Aryl or heteroaryl being themselves radical optionally substituted with one or more selected from Halogen Atoms and Radicals hydroxyl, alkyl, alkoxy, - COOH, - nr3r4, cooalk, conr3r4, nr3cor4 - oxo -, and cor3 cycloalkyl Radicals; In addition, heterocicloalquilo, ar ILO or heteroaryl radical optionally substituted with an alkylThe same radical optionally substituted with one or more selected from Halogen Atoms and Radicals hydroxyl, alkyl, alkoxy, - COOH, - nr3r4, cooalk, conr3r4 nr3cor4, -, - cor3; being nr1r2 so that R1 and R2 being either identical or different, one of R1 and R2 represents a unto Volume of hydrogen or an alkyl radical, and the other of R1 and R2 represents a hydrogen Atom,A radical optionally substituted cycloalkyl or an alkyl radical with one or several identical or different radical selected from hydroxyl radicals, alkoxy, nr3r4, heterocicloalquilo, heteroaryl or themselves, phenyl optionally substituted with one or several radical selected from The Halogen Atoms and Radicals hydroxyl alkyl, alkoxy, NH2,Nhalk and N 2 (alk); R1 and R2 are with the nitrogen Atom to which are attached a cyclic radical comprising of 3 to 10 links and optionally one or more heteroatoms (S) or between different chosen, S, N, NH, and this included the NH radical containing substituted option optional Finally, nr3r4 such that being well R3 and R4 are identical or different.One of R3 and R4 represents a hydrogen Atom or an alkyl radical, and the other of R3 and R4 represents a hydrogen Atom, an alkyl or cycloalkyl radical radical optionally substituted with one or several identical or different radical selected from hydroxyl radicals, alkoxy, and Rocicloalquilo themselves, or heteroaryl phenyl optionally substituted,With one or several radical selected from Halogen Atoms and Radicals hydroxyl, alkyl, alkoxy, NH2, and nhalk N (alk) 2; R3 and R4 form with the nitrogen Atom to which are attached a cyclic radical comprising of 3 to 10 links and optionally one or more heteroatoms di Various elected (S) between o, S, N and NHThis included the Optional containing NH radical optionally substituted; cyclic Radicals that can form R1 and R2 or R3 and R4 respectively with the nitrogen Atom to which they are United, being optionally substituted with one or several identical or different chose radical Between the two Halogen ATOMS, hydroxyl radicals, Oxo, alkoxy, NH2, nhalk,(alk) 2 radical and alkyl, cycloalkyl, heterocicloalquilo, co - co2alk alkyl, phenyl, phenyl heteroaryl - CH2, such that in these last heterocicloalquilo alkyl Radicals, radical, phenyl optionally substituted heteroaryl are themselves with one or several radical the Egidos between Halogen Atoms and hydroxyl radicals.Alkyl and alkoxy containing 1 to 4 carbon ATOMS, N and NH2; nhaik (alk) 2; R1, R2, R3 and R4 in the radical nr1cor2 nr3cor4 COR1, -, -, and - cor3 being selected among the meanings indicated above for R1, R2,R3 and R4 in nr1r2 and nr3r4 part when R1 and R2 and R3 and R4 form a cyclic radical with the nitrogen Atom to which they are United; comprising all alkyl and alkoxy Radicals (alk) above of 1 to 6 carbon Atoms; and such products of formula (1) in All Forms Isomeras possible enantiomers and Racemic, diastereoisomeras,As well as the addition salts with Mineral and organic acids or bases with Organic and Mineral Products of formula (1).