Polymorphic form of granisetron hydrochloride, Methods of making the same, comprising the pharmaceutical Composition and its use in the treatment of emesis.

摘要

Granisetron hydrochloride Crystalline characterized by an x-ray diffraction pattern with Peaks in dust and 14.3, 20.4 23.0 Plus Minus 0.2 degrees two Theta and process to produce approximately the same.Claim 1: granisetron hydrochloride Crystalline presents a pattern of x-ray Powder diffraction peaks at approximately 14.3, and 20.4 23.0 Plus Minus 0.2 degrees two Theta.Claim 2: granisetron hydrochloride Crystalline claim 1, which also shows an x-ray diffraction pattern with Peaks in dust and in approximately 18.2, 26.8 27.5 less 0.2 degrees two Theta.Claim 3: granisetron hydrochloride Crystalline claim 1, which also shows an x-ray diffraction pattern with Peaks in dust in approximately 25.6 22.3 17.5, and Plus Minus 0.2 degrees two Theta.Claim 1: granisetron hydrochloride Crystalline claim 1, which also presents a Spectrum Infrared Bands at approximately 3235, 2950, 2450, 1647 and 757 (cm - 1).