rapamycin 39-demethoxy derivative, compound or a pharmaceutically acceptable salt thereof, pharmaceutical composition, methods for treating fungal diseases or infections and for treating B cell cancer or malignancies, use of a compound, process for preparing of a compound, and, composition or kit of parts

摘要

39-DEMETOXI DERIVATIVE OF RAPAMYCIN, COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME, PHARMACEUTICAL COMPOSITION, METHODS FOR TREATMENT OF FUNGIC DISEASES OR INFECTIONS AND TREATMENT OF A CANCULA OR PROSAL CULUS OF A COMPOUND, AND, COMPOSITION OR PARTS KIT. The present invention relates to novel 39-demethoxy rapamycin derivatives, methods for their production, and uses thereof. In another aspect the present invention provides the use of these 39-demethoxy rapamycin derivatives in the treatment of cancer and / or B cell malignancies, the induction or maintenance of immunosuppression, the treatment of transplant rejection, graft disease vs. host disease, autoimmune disorders, inflammation disorders, vascular disease and fibrotic disorders, stimulation of neuronal regeneration or treatment of fungal infections.