Method and kit for the prognosis and assessment of the efficacy of the treatment of a solid tumor in a patient of interest; and method for the identification of markers that are prognostic of a solid tumor

摘要

Method and kit for the prognosis and assessment of the efficacy of the treatment of a solid tumor in a patient of interest; and method for the identification of markers that are prognostic of a solid tumor. The present invention provides methods, systems and equipment for the prognosis and assessment of treatment of solid tumours.Genetic markers that are prognostic of solid tumours may be identified in accordance with this invention each genetic marker has patterns of expression altered in PBMCs of patients with solid tumours after initiation of anticancer treatment, and the magnitudes of these The changes are correlated with clinical outcome of these patients.In one mode, uses a model of the Cox proportional hazards to determine the correlations between the clinical outcome of patients with RCC and changes in gene expression in PBMCs of patients during treatment with CCI 779. Non limiting examples of genes identified by Cox model are shown in tables 4a, 4b, 5A and 55.These genes can be used as surrogate markers for prognosis of RCC. Can also be used as indicators for the efficacy of farmacogenu00f3micos CCI 779 or other drugs antu00edcu00e2ncer.