4 - 4 - (4 - Chloro - - 3 - (trifluoromethyl) phenyl amino} Carbamoyl) - 3 - fluorofenoxil - N - metilpiridina - 2 - carboxamide Monohydrate

摘要

1. - a compound of the formula (ii). The Compound of claim 1 that shows the x-ray diffraction Peak of an angle 2 Theta 21.2. 3.The Compound of claim 1 that shows a peak in the FIR Spectrum of 353 cm - 1.4.- a procedure for the preparation of the compound of the formula (ii) of any of claims 1 to 3, which comprises Dissolving 4 - [4 - ({[4-chloro-3 - (trifluoromethyl) phenyl) amino Carbamoyl) - 3} - FLuorofenoxi] - N - metilpiridina - 2 - carboxamide and Add Water until precipitation occurs. 5.- the preparation of a compound of the formula (ii) of any of claims 1 to 3, which includes suspend 4 - [4 - ({[4-chloro-3 - (trifluoromethyl) phenyl] amino} Carbamoyl) - 3 - fluorofenoxi] - N - metilpIridina - 2 - carboxamide in aqueous Solvent and then Stir or Shake until the conversion occurs in the compound of the formula (d) 6.A compound of the formula (ii) of any of claims 1 to 3 for the treatment of disorders hiperproliferativos.7.A compound of the formula (ii) of any of claims 1 to 3 for the treatment of solid tumours, lymphomas, sarcomas, leukemias, breast cancers, respiratory tract,Brain, reproductive organs, digestive tract, urinary tract, Eye, Liver, Skin, Head and Neck, Thyroid, and / or paratiroides.8.Use of a compound of the formula (ii) of any of claims 1 to 3 for the preparation of a Pharmaceutical composition for the treatment of disorders hiperproliferativos, 9.- the use of claim 8 for the treatment of solid tumours, lymphomas, sarcomas, leukemias, breast cancers, respiratory tract, Brain, Reproductive OrgansThe digestive tract, urinary tract, Eye, Liver, Skin, Head and Neck, and / or Thyroid parathyroid Gland.