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Specific antagonists of VEGF for neoadjuvant and adjuvant Therapy and neoadjuvant Treatment of tumors and the treatment of tumors in early stages

机译:VEGF的新拮抗剂和新疗法的特异性拮抗剂和新疗法的治疗和早期肿瘤的治疗

摘要

1. - a Pharmaceutical composition comprising an effective amount of a specific antagonist of VEGF for use in the treatment of metastatic cancer, benign Precancerous or not. 2.The pharmaceutical Composition of claim 1, wherein the specific antagonist of VEGF is in an amount effective to prevent the metastatic cancer, benign Precancerous or not become invasive cancer or metastatic. 3.The pharmaceutical Composition of claim 1, wherein Said benign Precancerous or non metastatic cancer, is a cancer of Stage 0 Stage, stage I or II. 4.The pharmaceutical Composition of claim 3, wherein the specific antagonist of VEGF is in an amount effective to prevent the benign cancer, Precancerous or not progress to metastatic cancer Stage III or IV stage. 5.The pharmaceutical Composition of claim 1, wherein the specific antagonist of VEGF is in an amount effective to reduce the size of tumor. 6.A Pharmaceutical composition comprising a specific antagonist of VEGF for use in the treatment of a subject with a Family History of cancer, polyps, or a Hereditary Cancer Syndrome, where the specific antagonist of VEGF is in an amount effective to prevent L To the occurrence or recurrence of a benign metastatic cancer, Precancerous or not in that subject. 7.The pharmaceutical Composition of claim 6, wherein the specific antagonist of VEGF is in a sufficient amount to prevent the occurrence or recurrence of the Cancer, benign Precancerous or not metastatic in a Subject that has never had clinically detectable cancer Or a guy who has had cancer, benign. 8.A Pharmaceutical composition comprising a specific antagonist of VEGF for use in reducing the size of the tumor in a subject with an unresectable tumor, where the specific antagonist of VEGF is in an amount effective to reduce the size of the tumor, allowing ACE If complete resection of the tumor. 9.The pharmaceutical Composition of claim 8, further use after complete resection of the tumor.
机译:1-药物组合物,其包含有效量的VEGF特异性拮抗剂,用于治疗转移性癌症,无论是否为良性癌前。 2.根据权利要求1所述的药物组合物,其中所述VEGF的特异性拮抗剂的量有效预防转移性癌,良性癌前癌或不成为浸润性癌或转移性癌。 3.权利要求1的药物组合物,其中所述良性癌前癌或非转移性癌是0期,I或II期的癌症。 4.根据权利要求3所述的药物组合物,其中所述VEGF的特异性拮抗剂的量可有效预防良性癌症,癌前期或未进展至转移性癌症的III或IV期。 5.根据权利要求1所述的药物组合物,其中所述VEGF的特异性拮抗剂的量有效地减小了肿瘤的大小。 6.一种药物组合物,其包含VEGF的特异性拮抗剂,用于治疗患有癌症,息肉或遗传性癌症综合征的家族史的受试者,其中所述VEGF的特异性拮抗剂的量可有效地预防L。良性转移性癌症的发生或复发,在该受试者中是否为癌前期的。 7.根据权利要求6所述的药物组合物,其中所述VEGF的特异性拮抗剂的量足以防止从未经历过临床可检测到的癌症的受试者或患有该疾病的一个人的癌症,良性癌前或不转移的癌症的发生或复发。得了癌症,良性。 8.一种药物组合物,其包含VEGF的特异性拮抗剂,用于减少患有不可切除的肿瘤的患者的肿瘤大小,其中所述VEGF的特异性拮抗剂的量有效地减少了肿瘤的大小,从而允许ACE完全切除肿瘤。 9.权利要求8的药物组合物,在肿瘤完全切除后进一步使用。

著录项

  • 公开/公告号CO6210829A2

    专利类型

  • 公开/公告日2010-10-20

    原文格式PDF

  • 申请/专利权人 GENENTECH INC;

    申请/专利号CO20090074843

  • 申请日2009-07-17

  • 分类号A61K38/17;

  • 国家 CO

  • 入库时间 2022-08-21 18:47:14

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