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NEW TRIAZABENZO α NAFTO 2,1,8-cde AZULENA COMPOUNDS, METHOD OF THEIR PRODUCTION AND CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS

机译:新的三氮杂苯[α]纳富特[2,1,8-cde]阿祖兰化合物,其生产方法和含有其药物成分

摘要

The compounds of formula (I) where R is hydrogen, (C — C) alkyl, (C — C) aminoalkyl or (C — C) hydroxyalkyl, R is hydrogen, or R and R, together with their carbon atoms, form a carbon- carbon, R 1 is hydrogen, R 1 is hydrogen, methyl or (C-C) alkyl, (C-C) aminoalkyl, (C-C) hydroxyalkyl, aryl- (C-C) alkyl or heterocycloalkyl- (C-C) alkyl , or R and R, together with the carbon atoms that carry them, form a carbon-carbon bond, R, R, R and R are hydrogen, or a pair of substituents attached to the same atom (R R and / or R and R) form an oxo, thioxo or imino group, R is hydrogen, halogen, (C-C) alkyl, (C-C) alkoxy, hydroxy, cyano, nitro, (C-C) polyhaloalkyl or optionally substituted amino , R and R are hydrogen, halogen, (C — C) alkyl, (C — C) alkoxy, hydroxy, cyano, nitro, (C — C) polyhaloalkyl or optionally substituted amino, n is an integer from 0 to 4 inclusive, m represents an integer from 0 to 2 inclusive, p represents an integer from 0 to 3 inclusive, X represents a group NR, R represents dorod, (C — C) alkyl, (C — C) alkenyl, aryl- (C — C) alkyl or (C — C) polyhaloalkyl, their enantiomers, diastereoisomers and N-oxides, as well as their pharmaceutically acceptable acid addition salts thereof or base. Medicines
机译:其中R是氢,(CC)烷基,(CC)氨基烷基或(CC)羟烷基,R是氢或R 1和R 2的式(I)化合物与它们的碳原子一起形成a R 1是氢,R 1是氢,甲基或(CC)烷基,(CC)氨基烷基,(CC)羟烷基,芳基-(CC)烷基或杂环烷基-(CC)烷基,或R和R,与携带它们的碳原子一起形成碳-碳键,R,R,R和R为氢,或与同一原子相连的一对取代基(RR和/或R和R)形成氧代,硫代R 1为氢,卤素,(CC)烷基,(CC)烷氧基,羟基,氰基,硝基,(CC)多卤代烷基或任选取代的氨基,R和R为氢,卤素,(CC)烷基, (CC)烷氧基,羟基,氰基,硝基,(CC)聚卤代烷基或任选取代的氨基,n为0至4的整数,包括m,m为0至2的整数,p为0的整数到3(含3),X代表基团NR,R代表发送了多洛德,(CC)烷基,(CC)烯基,芳基-(CC)烷基或(CC)聚卤代烷基,它们的对映异构体,非对映异构体和N-氧化物,以及其药学上可接受的酸加成其盐或碱。药物

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