PHARMACEUTICAL COMPOSITION FOR TREATING TUBERCULOSIS AND DISEASES MEDIATED BY HELICOBACTER PYLORI BASED ON SOLID LIPID NANOPARTICLES AND A METHOD FOR THE TREATMENT OF TUBERCULOSIS

摘要

The invention relates to a medicine, pharmacy and antitubercular preparations, namely, to the solid lipid nanoparticles (SLN)-based pharmaceutical composition for treating tuberculosis and diseases mediated by Helicobacter pilory, where this pharmaceutical composition contains a therapeutically effective amount of antitubercular antibiotics, selected from rifabutin and rifampicin, which are sorbed into the lipidic matrix, which consists of a combination of one or more long-chain fatty acids esters, cholesterol or its pharmaceutically acceptable derivative, and phospholipid. The invention also relates to the method of treating tuberculosis and diseases mediated by Helicobacter pilory, which method includes a peroral administration of solid lipid nanoparticles (SLN)-based pharmaceutical composition according with the invention in a therapeutically effective amount to a patient(s) needs thereof, in a certain therapeutic regime. The invention, versus a prototype, enables a higher drug-loading of solid lipid nanoparticles and a higher antitubercular activity.