BIOLOGICALLY ACTIVE PROTEINS WITH IMPROVED STABILITY IN VIVO AND / OR IN VITRO

摘要

The present invention relates to biologically active proteins containing at least two domains, where the first domain of said at least two domains contains an amino acid sequence having and / or mediates said biological activity, and the second domain of said at least two domains contains an amino acid a sequence consisting preferably of at least about 100 amino acid residues forming a random coil conformation, whereby said conformation is tea ball mediates the increased stability of said biologically active protein in vivo and / or in vitro. The following discloses nucleic acid molecules encoding the biologically active proteins of the invention, vectors, and cells containing said nucleic acid molecules. In addition, the present invention provides compositions containing compounds of the invention, as well as specific uses of biologically active proteins, nucleic acid molecules, vectors and cells of the invention.