PHARMACEUTICAL COMPOSITIONS FOR USE AS MEDICAMENTS FOR PREVENTING OR TREATING A SIDE EFFECT OF OPIOIDS COMPRISING AN OPIOID IN COMBINATION WITH A PERIPHERAL MU OPIOID ANTAGONIST COMPOUND

摘要

Novel methods and compositions comprising opioids and opioid antagonists. In preferred embodiments, the methods and compositions comprise opioids and peripheral mu opioid antagonist compounds. The methods and compositions are particularly suitable for treating and/or preventing side effects associated with opioids including, for example, constipation, vomiting and/or nausea.