A METHOD FOR MANUFACTURE OF SERTINDOLE, COMPRISING THE STEP OF PREPARING 5 - CHLORO - 1 - (4 -FLUOROPHENYL) - INDOLE FROM 5 - CHLORO - INDOLE AND 4 - FLUOROPHENYL - HALIDE IN THE PRESENCE OF COPPER SALT AS CATALYST

摘要

The present invention relates to a novel method for manufacture of sertindole comprising manufacturing 5-chloro-1-(4-fluorophenyl)-indole and converting it to sertindole wherein the method for manufacture of 5-chloro-1-(4-fluorophenyl)-indole comprises reacting 5-chloro-indole with a 4-fluorophenylhalide in the presence of a base, a chelating ligand and catalytic amounts of a copper salt comprising copper(I) or copper(II) and an anion which does not interfere in an unfavourable way with the reaction.