A PROCESS FOR PREPARATION OF (3R,5S,6E) 6-{2-4-(4-FLUORO-PHENYL)-6-ISOPROPYL-2-(METHANESULFONYL-METHYL-AMINO)-PYRIMIDIN-5-YL}-VINYL}-2,2-DIMETHYL-1,3 DIOXAN-4-YL)-ACETIC ACID, CALCIUM SALT (ROSUVASTATIN ACETONIDE CALCIUM)

摘要

ABSTRACT The present invention is in relation to a process for preparation of HMG-CaO reductase inhibitor. More particularly, the present invention provides a process for preparation of (3R,5S,6E) 6-{2-[4-(4-Fluoro-phenyl)-6-isopropyl 2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]-vinyl}-2,2-dimethyl-[l,3]dioxan-4-yl)-acetic acid ,calcium salt (Rosuvastatin acetonide calcium) which is used for treating hypercholesterolemia.