MEROPENEM INTERMEDIATE IN NOVEL CRYSTALLINE FORM

摘要

The present invention specially relates to the crystalline form of (4-Nitrobenzyl (4R.5S,6S)-(3-{(3S,5S)-5-[(dimethylamino)carbonyi]-l-[(4-nitrophenoxy)carbonxyl] pyrroIidin-3-yl}thio-6- [(lR)-l-hydorxyethyl]-4-methyl-7-oxo-l-azabicyclo[3.2.0].hept-2-ene-2-carboxylate)of compound formula -I as well as an improved process for preparation of meropenem trihydrate of compound formula-II Wherein, PNB represent P-nitro benzyl group and PNZ represent P- nitrobenzyloxycarbonyl group.