Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem

摘要

The present invention relates to novel crystalline form of (4-Nitrobenzyl (4R,5S,6S)-(3-{(3S,5S)-5-[(dimethylamino)carbonyl]-1-[(4-nitrophenoxy)carbonxyl]pyrrolidin-3-yl}thio-6-[(1R)-1-hydorxyehtyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0].hept-2-ene-2-carboxylate) of compound Formula I as well as an improved process for the preparation of meropenem trihydrate of compound Formula II; wherein, PNB represent P-nitro benzyl group and PNZ represent P-nitrobenzyloxycarbonyl group.