IMPROVED PROCESS FOR RACEMIZATION OF (R)-3- (DIMETHYLAMINO)-1-(2-THIENYL)-1-PROPANOL, FORMED DURINGTHE SYNTHESIS OF DULOXETINE HYDROCHLORIDE

摘要

The present invention relates to an improved process for the racemization of (R)-3- (dimeth);lamino)-1-(2-thienyl)-l-propanol, an undesired enantiomer formed during synthesis of duloxetine hydrochloride, using an aqueous organic acid. The process according to present invention is safe, eco-friendly, high yielding and avoids use of highly corrosive acids.