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Compounds and methods for double labelling of polypeptides to allow multiplexing in mass spectrometric analysis
Compounds and methods for double labelling of polypeptides to allow multiplexing in mass spectrometric analysis
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机译:用于多肽双标记以允许在质谱分析中进行多重化的化合物和方法
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摘要
The present invention describes double labelling reagents with both an isotopic and isobaric label component suitable for differentially labelling different - protein samples. After labelling of the individual protein samples, all samples are pooled. Peptides from the pooled samples are isolated and analysed by mass spectrometry for determining the relative concentration of each differentially double-labelled polypeptide.
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