NOVEL PROCESS FOR SYNTHESIS OF ENANTIOMERICALLY PURE (R) 5- (1R)-1-(4-ALKYLPIPERAZIN-1-YL) ETHYL-2 METHOXYBENZENESULFONAMIDE

摘要

Where R is C1-C3 alkyl, alkenyl A novel process for synthesis of compound of Formula 1 comprising steroselective catalytic reduction of compound of Formula IV under hydrogen gas pressure to obtain an intermediate compound of Formula II , which on coupling in presence of coupling agent and base in presence of organic solvent to obtain compound of Formula X , Formula X on reacting with deprotecting agent in presence of organic solvent results in formation of compound of Formula XI, condensation of Formula XI with alkyl halide results in formation of compound of Formula I.