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NON-SPHERICAL CONTRAST AGENTS FOR CEST MRI BASED ON BULK MAGNETIC SUSCEPTIBILITY EFFECT
NON-SPHERICAL CONTRAST AGENTS FOR CEST MRI BASED ON BULK MAGNETIC SUSCEPTIBILITY EFFECT
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机译:基于大块磁化率效应的CEST MRI非球面造影剂
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摘要
In magnetic resonance imaging (MRI) based on chemical exchange-dependent saturation transfer (CEST), a novel carrier for CEST contrast agents is provided. The carrier is non-spherical and comprises a semipermeable shell, wherein the shell comprises a paramagnetic compound. The shell encloses a cavitycomprising an MR analyte, wherein the semipermeable shell allows diffusion of the MR analyte. The CEST effect is based on the 5 bulk magnetic susceptibility effect caused by the anisotropy of the carrier. This leads to a versatile carrier that does not require interaction of the analyte with a paramgnetic chemical shift reagent.
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