New compounds and their effects on food behavior.

摘要

The invention provides a peptide, which includes the amino acid sequence described below, and the use and method thereof. Peptides are particularly useful in suppressing appetite and treating obesity. 22 22 22 22 22 22 22 22 22 22 22 22 22 22 xa18 xa19 xa20 Xa21 Xa22 Xa23 xa24 is: G1U15 GLU16 G1U17 LEO18 Val19 LYS20 TYR21 P22 LEO23 GLU24，GLU15 GLU15 GLU15 GLU16 GLU16 GLU17 L18 Val19 LL19 L20 TyR21 P22 22 22 L22 L23 GLN24，GLU15 GLU15 GLU15 L19 L18 L18 L18 L19 L19 L24，GLU15 L15 GLU16 GLU18 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L22 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 L19 Lys20 Tyr21 P22 Il23 GLU24，GLU15 GLU16 GLU17 Il18 Val19 LYS20 TYR21 P22 Iel23 GLN24，GLU15 GLN16 GLU17 LU17 val19 LYS20 TYR21 P22 LY23 GLU24，GLU15 GLN16 G1U17 L1U17 L17Ll18 GLU22 Iles23 GLU24，GLU15 GLN16 GLU17 L19 LY22O，LY2O22 L22L2O23 GLU24，GLU15 L1N16 GL16 GLU17 GLUB17 LY17 LY2O21GLU15 GLN16 GLU17 Il18 Val19 LY20 TYR21 P2222 LE23 GLU24，GLU15 GLN16 GLU17 Ile18 val19 LYS20 TYR21 LE23 GLN24，GLU15 GLN16 GLU17 Ile18 val19 LY2O TYR21 GLU22 Ile23 GLU24，GLU15 GLN16 GLU17 Ile18 Val19 LYS20 GLN24，or ASP15 Ser16 Arg17 18 AL19 GLN20 ASP21 Xa27 xa27 xa28 xa29 xa29 xaa31 xaa32 is: met27 asn28 thr29 lys30 arg31 asn32, ly27 asn28 ala29 gly30 pro31 ser32, or ly27 asn28 gly29 gly30 pro31 ser32 or a peptide as described above, wherein the asn34 residue is replaced by asn34; or a peptide as described above, xa3 is glu3;The condition is that if xaal5 xaal6 xaal7 xaal8 xaal9 xaal20 xaal0 xaal0 xaal21 xaal21 xaa24 is asp15 ser16 arg17 arg18 ala19 gln20 asp21 ph2222 val23 gln24, then xa27 xaa28 xa29xaa30 xaa32 is not met27 asn28 thr29 lys30 arg31 asn32.