Collagen type IX alpha 1 chain NC4 domains for treating arthritis

摘要

Disclosed are compositions comprising a polypeptide comprising a collagen type IX alpha (1) chain NC4 domain having anti-arthritic or anti-inflammatory activity and a molecular weight of less than 30,000Da, which is capable of tolerising individuals to antigenic components of cartilage and preventing the appearance of symptoms of arthritis. Also disclosed are methods for recovering these polypeptides from connective tissue.