Diazabicyclic aryl derivatives as cholinergic receptor modulators and nicotinic acetylcholine receptor ligands

摘要

Disclosed are 1,4-diaza-bicyclo[3.2.2]nonane derivatives as represented by Formula I, which are cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters, wherein n is 1, 2 or 3; and A represents a phenyl, a thiadiazolyl, a pyridyl or a pyridazinyl group; B represents a phenyl group, a thiadiazolyl group, a pyridyl group or a pyridazinyl group, which may optionally be substituted one or more times with substituents selected from the group consisting of alkyl, cycloalkyl, hydroxy. alkoxy, cyano-alkyl, halo, trihaloalkyl, trihaloalkoxy, cyano, amino, nitro, and -NH(CO)R""; wherein R"" represents hydrogen, alkyl or cycloalkyl; and L represents a linking group selected from C2-alkynyl, -O-, -S-CH2-, -SO-, -S-, -NHCO-, -NHCONH- or -NH(SO2)-.