Oxylipins from long chain polyunsaturated fatty acids including docosapentaenoic acid and docosatetraenoic acid (DPA and DTA) and methods of making and using the same

摘要

Disclosed is an isolated docosanoid of docosapentaenoic acid (DPAn-6), wherein the docosanoid is an R- or D-epimer of a docosanoid selected from the group consisting of: 8-hydroxy DPAn-6; 10-hydroxy DPAn-6; 11-hydroxy DPAn-6; 13-hydroxy DPAn-6; 7,17-dihydroxy DPAn-6; 10,17-dihydrocy DPAn-6; 13,17-dihydroxy DPAn-6; 714-dihydrocy DPAn-6; 8,14-dihydroxy DPAn-6; 16,17-dihydroxy DPAn-6; 13,17-dihydroxy DPAn-6; 7,14-dihydroxy DPAn-6; 8,14-dihydroxy DPAn-6; 16,17-dihydroxy DPAn-6; 4,5-dihydroxy DPAn-6; 7,16,17-trihydroxy DPAn-6; and 4,5,17-trihydroxy DPAn-6; or a derivative or salt thereof.